This book presents development of an in vitro human cells based test system that is suitable for pre-clinical studies of drugs and assessment of adverse effects of various chemical compounds. As a consequence results of toxicological studies in animals can lead to false conclusions and termination of development of drug candidates potentially beneficial to humans and also to continued development of drug candidates that later show to be toxic to humans. Traditionally preclinical toxicological studies are performed on animals. The system is based on rotary vessels that simulate growth in microgravity conditions allowing the cells to grow continuously for months and create cell conglomerates that resemble normal liver tissue. Testing of drugs can be performed for hours or weeks/months to follow acute or chronic toxicity respectively. Pharmaceutical and, to a lesser degree, most other consumer products are routinely tested for safety. Metabolism of drugs and toxic compounds in many cases is different in test animals and humans.
Molecular Markers Associated with Hepatotoxicity. Development of in vitro test system based on human cells
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Книга по Требованию
Клініко-лабораторна характеристика дітей з спадковою алергічною схильністю, корекція...
Mag ium i blood serum a d he i crease of phosphorus i childre wi h ge e ic a opy a he pre osological s age already was fou d ou . he de ec io of he level IL-4 of childre wi h i heri ed a opy was offered as a marker of he ra sforma io of ge e ic allergic predisposi io i o allergic disease. he rehabili a io a d preve io arra geme s were developed a d es ed for childre wi h allergic predisposi io aimed a he preve io of he ra sforma io of ge e ic allergic predisposi io i o allergic disease. he complex recomme ded i cludes Mag esium, e erosorbe s, probio ics, membra es abilizers, e zyma ic age s.
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Despite the considerable knowledge of insect pests at the molecular level, this information comes mostly from ' model' organisms such as the the fruit fly (Drosophila melanogaster).