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The Biosynthesis Pathway of PyrroloQuinoline Quinone (PQQ). Master's thesis in structural biology

Формат:      Страниц 52
     мягкая обложка
Moritz M.    
Книга по Требованию    
1997 руб
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The biosynthesis pathway of PyrroloQuinoline Quinone, a bacterial redox active cofactor for numerous dehydrogenases, is largely unknown, but it is known that at least six genes PqqA-F) are required, all of which are located in the PQQ-operon. New structural data of some PQQ biosynthesis proteins and their homologues provide new insights and functional assignments of the proteins in the pathway. Based on sequence analysis and homology models I propose the role and catalytic function for each enzyme involved in this intriguing biosynthesis pathway. PQQ is derived from the two amino acids glutamate and tyrosine encoded in the precursor peptide PqqA. Five reactions are necessary to form this quinone cofactor. The PqqA peptide is recognised by PqqE, which links two carbon atoms, afterwards it is accepted by PqqF which cuts out the linked amino acids. The next reaction (Schiff base) is spontaneous, the following dioxygenation is catalysed by an unknown enzyme. The last cyclization and oxidation steps are catalysed by PqqC. Taken together the known facts of the different proteins I assign a putative function to all six proteins in the PQQ biosynthesis pathway.
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Теоретические аспекты между бюджетами всех уровней с помощью деятельности Федерального...
Выпуск продукции составил 3 889 тыс.руб., что на 36 процентов меньше, чем в первом полугодии 2001 года. Из 38 видов промышленной продукции, учитываемых в срочной отчетности, по 20 (53 процента) видам наблюдается рост объемов производства. Поступления в бюджетную систему территории в первом полугодии 2002 года номинально увеличились по сравнению с соответствующим периодом прошлого года на 150 процентов, и составили 549 039 тыс.рублей. Значительная тенденция увеличения прослеживается и с учетом корректировки на сводный индекс потребительских цен (122,8 процента), таким образом реальная сумма поступлений, увеличилась на 213 процентов и составила 447 100 тыс.рублей. Поступления во внебюджетные фонды уплачиваемые в части единого социального налога (взноса) составили 204 192 тыс. рублей, 27 процентов от общего объема поступлений налогов и сборов на территории городов. 3 процента от общего объема поступлений налогов и сборов отчисленного во внебюджетные фонды приходится на единый налог на вмененный доход. Доля доходов внебюджетных фондов в консолидированном бюджете территории составляет 28 процентов. Приложение № 1. Существенно изменились пропорции распределения доходов между бюджетами разных уровней.

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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online.
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Here I introduce a novel CCV-associated protein with a serine/threonine kinase homology domain, called CVAK104 (Coated-Vesicle-Associated-Kinase of 104 kDa).
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