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A pharmacogenetic approach to identify the causes of strain-specific responses in rat and rabbit Genetic background and the response to anaesthetics and analgesics.

Формат:      Страниц 124
     мягкая обложка
Автор:
Harutyun A.    
Издательство:
Книга по Требованию    
Год:2009
Цена:
2416 руб
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The response of (laboratory) animals to anaesthetics and analgesics shows intraspecies variability. In the studies described in this book, rabbit and rat inbred strains were used to identify differences in response to anaesthetics and analgesics. Parameters for a genetic analysis were thus provided to identify candidate genes involved in this variability. This book will aid medical and veterinary researchers in the development of tailored anaesthesia. Both in the rat and rabbit,significant strain differences were observed in the response to a variety of commonly used anaesthetics and analgesics in (laboratory animal) medicine. In the rats it was demonstrated that buprenorphine administration did not only result in strain-specific responses to its analgesic but also to its behavioural effects. This response was then genetically analyzed and candidate genes were identified on the rabbit genetic map. Besides environmental influences, genetic factors might be involved in this phenomenon. The difference in response to medetomidine between two rabbit strains was linked to differences in the anaesthetic’s biotransformation rate.
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Коригування зовнішніх дисбалансів платіжного балансу (на прикладі розвинутих...
Устранить их возможно лишь при проведении этими странами скоординированной макроэкономической политики, направленной на уменьшение их внешних дисбалансов таким образом, чтобы не ухудшить внешние позиции других стран. Выделены основные внутренние экономические факторы, влияющие на сбережения и инвестиции и, как следствие, на текущий счет платежного баланса. Среди них основное место занимают темпы роста национального дохода, темпы роста производства, условия торговли, а также демографический фактор, который в последнее время приобретает все большее значение. Отдельно рассматривается современная демографическая ситуация, прогнозы относительно ее дальнейшей динамики, а также ее влияние на текущий счет отдельной страны. Кроме того, анализируется влияние демографических сдвигов на глобальный дисбаланс посредством их влияния на текущий счет Японии, который является одним из основных факторов, определяющих величину глобального дисбаланса. Ключевые слова: платежный баланс, текущий счет, экономический рост, глобальный дисбаланс, сбережения, инвестиции, демографический фактор. A O A IO A isimova O.Y. Adjus me of ex er al imbala ces of he bala ce of payme s (for developed cou ries). – Ma uscrip . his disser a io is for ob ai i g Ph.D. Degree i Eco omic Scie ces by specialisa io , coded 08.00.02. – World Eco omy a d I er a io al Eco omic Rela io s. – I s i u e of I er a io al Rela io s of Kyiv aras Shevche ko a io al U iversi y, Kyiv, Ukrai e, 2008. his Disser a io i ves iga es heore ical a d prac ical aspec s of he impac of eco omic fac ors o he bala ce of payme s of a cou ry. he mai approaches o he curre accou of he bala ce of payme s i cludi g key fac ors for each approach are co sidered. he i erdepe de ce be wee curre accou bala ce a d grow h ra e is a alysed. he mai macroeco omic ide i ies of he bala ce of payme s a d heir rela io wi h he sys em of macroeco omic i dica ors are fou d ou . he causes of he global imbala ces a d he ways o elimi a e hem are exami ed.


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