This book describes the use of artificial neural networks (ANN) as robust nonlinear modeling tools for developing quantitative structure-pharmacokinetic relationships (QSPkR). Different ANN paradigms are examined for predictive modeling of various pharmacokinetic parameters, both individually and simultaneously. A valuable resource for medicinal chemists and pharmaceutical scientists engaging in structure-property and structure-activity modeling. As well as providing the theory behind ANN model construction, this book details their practical application in pharmaceutical research and gives meaning to many of the theoretically-derived molecular descriptors now available. Modeling absorption, distribution, metabolism and excretion (ADME) using experimentally-derived data is time-consuming and expensive. Consideration is given to physiological processes, drug and molecular structural data, and model interpretation. Early pharmacokinetic optimisation is a key principle in drug discovery and development. The use of computational in silico techniques to predict pharmacokinetic properties based on molecular structure is gaining wider validity and acceptance in the pharmaceutical industry.
Quantitative Structure-Pharmacokinetic Relationships. Artificial Neural Network Modeling
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Книга по Требованию
105 лучших игр для всей семьи. Эта волшебная коробка займет достойное место в вашем доме. В ней есть все для того, чтобы сыграть всей семьей в 105 лучших игр всех времен368 рубРаздел: Прочие
Развитие сетевых операционных систем. Windows 2000
Революционность Wi dows 2000 заключается не в ядре операционной системы и не в пользовательском интерфейсе. Революционность составляют ряд крайне важных сверхструктур, устраняющих остатки наследия LA Ma ager из среды . В число важнейших характеристик Wi dows 2000 входят: Ac ive Direc ory – служба каталогов; Microsof Ma ageme Co sole (MMC) – стандартизированный, основанный на компонентах инструмент для административного управления системой; Dis ribu ed File Sys em – обеспечивает возможность создания распределённой файловой системы; Dis ribu ed COM (DCOM) – обеспечивает возможность создания распределённых приложений; Ac ive Direc ory Services I erface (ASDI) – стандартизированный интерфейс для всевозможных служб каталогов; Dy amic Domai ame Service (DD S) – замещает имевшуюся ранее WI S; Ac ive Desk op – новый, Web-ориентированный пользовательский интерфейс Wi dows; Wi 32 Driver Model (WDM) – новая архитектура драйверов. Кроме перечисленных характеристик в Wi dows 2000 реализовано множество важнейших (хотя и не столь выдающихся) характеристик, имеющих отношение к файловой системе управлению сетью и системной безопасностью.
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Additionally, when physicochemical properties or structures are expressed by numbers, one can form a mathematical relationship, or quantitative structure-activity relationship, between the two.
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Exercises accompanying each chapter and further readings on recent loans and the legal and medical vocabulary of English will be available online in the near future. • Introduces students to some basic linguistic terms needed for the discussion of phonological and morphological changes accompanying word formation • Designed to lead students to a finer appreciation of their language and greater ability to recognize relationships between words and discriminate between meanings • An informative appendix discusses the history and usefulness of the best known British and American dictionaries • Online readings and exercises to deepen and strengthen knowledge acquired in the classroom
• Both an introduction to some of the basic principles of linguistic analysis and a helpful manual for vocabulary discernment and enrichment • On-line readings and exercises designed to deepen and strengthen the knowledge acquired in the classroom • Designed to lead students to a finer appreciation of their language and greater ability to recognize relationships between words and discriminate between meanings English Words:
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The liberalization of the citrus sector caused a drastic change in industry structure with far-reaching consequences for conduct and performance.
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Our current results suggest that the inner layer of a DWNT can not fluoresce, which is contrary to the conclusion in the published literature.
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A number of topics are covered that needed to be addressed in the development of the method. They include: a new laboratory test to determine the soil diffusivity based on measuring soil sample volume changes, instead of suction measurements, with time; a design chart relating the soil diffusivity at field to soil diffusivity determined at lab addressing network of soil cracks; the derivation of a new closed form solution for the soil mound shape by using Mitchell’s equations for moisture diffusion under a partially covered soil; the results of suction change at the soil surface based on finite element simulations of a weightless cover on shrink-swell soils; new design procedure for slab-on-grade foundations on shrink-swell soils based on soil-structure-weather interaction finite element analyses.
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During sustainability management procedures, reporting fulfils a transversal task and guides through the stages on the road to long term sustainable success. “Sustainability Performance Reporting" is addressed to students, executives, consultants or environmental officers in the field of environmental and sustainability management. It facilitates awareness for sustainability relevance, provides environmental benchmarking and motivates towards change of value and behaviour. Reporting is a significant critical success factor for a sustainable development across all industries, and respective for the business case of this book, the packaging industry, an overall willingness to report and disclose information is determinable.
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