This book describes the use of artificial neural networks (ANN) as robust nonlinear modeling tools for developing quantitative structure-pharmacokinetic relationships (QSPkR). Different ANN paradigms are examined for predictive modeling of various pharmacokinetic parameters, both individually and simultaneously. A valuable resource for medicinal chemists and pharmaceutical scientists engaging in structure-property and structure-activity modeling. As well as providing the theory behind ANN model construction, this book details their practical application in pharmaceutical research and gives meaning to many of the theoretically-derived molecular descriptors now available. Modeling absorption, distribution, metabolism and excretion (ADME) using experimentally-derived data is time-consuming and expensive. Consideration is given to physiological processes, drug and molecular structural data, and model interpretation. Early pharmacokinetic optimisation is a key principle in drug discovery and development. The use of computational in silico techniques to predict pharmacokinetic properties based on molecular structure is gaining wider validity and acceptance in the pharmaceutical industry.
Quantitative Structure-Pharmacokinetic Relationships. Artificial Neural Network Modeling
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Книга по Требованию
Настольная игра "Лови мышей". «Лови мышей!» - быстрая веселая семейная игра с простыми правилами. Игроки выступают в роли котов, которые хотят поймать как можно больше567 рубРаздел: Прочие
Развитие сетевых операционных систем. Windows 2000
Революционность Wi dows 2000 заключается не в ядре операционной системы и не в пользовательском интерфейсе. Революционность составляют ряд крайне важных сверхструктур, устраняющих остатки наследия LA Ma ager из среды . В число важнейших характеристик Wi dows 2000 входят: Ac ive Direc ory – служба каталогов; Microsof Ma ageme Co sole (MMC) – стандартизированный, основанный на компонентах инструмент для административного управления системой; Dis ribu ed File Sys em – обеспечивает возможность создания распределённой файловой системы; Dis ribu ed COM (DCOM) – обеспечивает возможность создания распределённых приложений; Ac ive Direc ory Services I erface (ASDI) – стандартизированный интерфейс для всевозможных служб каталогов; Dy amic Domai ame Service (DD S) – замещает имевшуюся ранее WI S; Ac ive Desk op – новый, Web-ориентированный пользовательский интерфейс Wi dows; Wi 32 Driver Model (WDM) – новая архитектура драйверов. Кроме перечисленных характеристик в Wi dows 2000 реализовано множество важнейших (хотя и не столь выдающихся) характеристик, имеющих отношение к файловой системе управлению сетью и системной безопасностью.
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