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Vaccines and Hypervariable Viruses. Design and Development of HIV-1, HCV, and SARS-CoV Candidate Vaccines

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Ali A.    
Книга по Требованию    
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However, there is strong evidence that humoral and especially cellular immune responses play crucial roles in the control of established RNA viral infections. In the third study, a high level of specific SARS-CD8+T-cell response was demonstrated in mice that received DNA vaccine expressing the SARS-nucleocapsid, protein and XIAP (X-link inhibitor of apoptosis) as an adjuvant. In the first study, we showed that a combination of monocistronic DNA constructs expressing HIV-1 structural genes, HIV-1 recombinant proteins and a potent adjuvant is able to induce humoral and cellular immune responses in HLA. A2. 1 mice. In the second HIV-1 study, a synergistic effect between HIV- 1 and hepatitis C (HCV) immunogens was detected that may lead to induction of multi-specific immune responses against both HIV and HCV. Herein, correlates of protective immunity against HIV-1, HCV and SARS- CoV were assessed by various strategies. It is difficult to induce protective immunity against most RNA viruses.
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Розробка живої культуральної вакцини проти вірусної діареї великої рогатої...
На сьогодні немає сумніву, що в патології молодняка великої рогатої худоби вірусна діарея є однією з провідних інфекцій. В Україні, на жаль, вірусній діареї приділяється недостатньо уваги, що створює передумови її значного поширення в різних регіонах нашої країни. Значні економічні збитки, яких завдає вірусна діарея, зумовлені вищезазначеними особливостями її збудника та різноманітними формами перебігу. Найбільш ефективним засобом боротьби з вірусною діареєю великої рогатої худоби є вакцинація сприйнятливого поголів cells wi h he fi al i fec ious ess i le of 7,6 lg ТCID 50/см3, ac ively i duces virus eu ralizi g a ibodies i he orga isms of he vacci a ed a imals. Proposed cells a d virus cul iva io ech ology allows o ob ai o -co ami a ed wi h ex ra eous microflora (by bac eria, ca dida, viruses), harmless for a imals a d highly immu oge ic vacci e. I a dose 2Ч105,45 ТCID 50/a imal wi h a simul a eous i jec io wi h bac erial lipopolysaccharide from he calcula io of 7 mkg/kg of a imal mass, wice wi h a for igh i erval, i ac iva es all li ks of he immu e sys em i he orga ism of he vacci a ed a imals, providi g i duc io of virus eu ralizi g a ibodies i i les o 8,0 log2 a d defe se agai s virus diarrhea. he developed projec of orma ive docume s o a vacci e alive cul ural agai s virus diarrhea of ca le is se for exami a io of he S a e Scie ific Co rol I s i u e of Bio ech ology a d S rai s of Microorga isms a d coordi a io a he S a e Depar me of Ve eri ary Medici e of Ukrai e.

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