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| | |  | | Наименование: | Analysis of Interval-Censored or Aggregated Point Process Data. A Local Likelihood Approach | | Формат: | Страниц 112
мягкая обложка | | Автор: | Chun-Po S.F.  | | Издательство: | Книга по Требованию | | Год: | 2010 | | Цена: | | | |
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| We consider local EM to analyze point process data that are either interval-censored or aggregated into counts. The use of local likelihood methods (Tibshirani and Hastie, 1987; Loader, 1996) in the presence of interval-censored or aggregated data leads to a natural consideration of an EM-type strategy, or a local EM algorithm. We present the formulation of local EM algorithms to estimate density, intensity and risk and their implementations using piecewise constant functions. From a theoretical perspective, local EM and the EMS algorithm complement each other. We demonstrate that an EMS algorithm rises naturally from a local likelihood consideration in the context of point processes while the EMS algorithm serves as a rapid implementation of local EM algorithms and provides theoretical tools to better understand the role of local EM. It is shown that the use of the piecewise constant function at the E-step explicitly results in an iteration that involves an expectation, maximization and smoothing step, or an EMS algorithm considered in Silverman et al. (1990). Consequently, we reveal a previously unknown connection between local EM and the EMS algorithm. |
Оптимізація хірургічного лікування діабетичної...
Установлено, что у наблюдавшихся больных отмечаются значительные нарушения в системе АОЗ на фоне активации ПОЛ в крови и тканях гнойной раны. Это приводит к интоксикации организма, нарушению фазности репаративных процессов в ране. Нами был разработан способ местной фотохимической антиоксидантной терапии, применение которой позволило уменьшить активность ПОЛ и стабилизировать функцию системы АОЗ. На фоне такого лечения в короткие сроки уменьшается интоксикация организма, активируются репаративные процессы в ране. Обнаружено, что сочетание фотохимической терапии и системной энзимотерапии у таких больных обеспечивает фазность течения репаративных процессов и уменьшает сроки лечения на 7,05 суток, а количество осложнений снижает с 16,9 % до 11,2 %. Ключевые слова: сахарный диабет, местное фотохимическое воздействие, перекисное окисление липидов, антиоксидантная защита, апоптоз, серратиопептидаза. SUMMARY Dolgopolov V.V. Op imiza io of surgical medical rea me of diabe ic foo . – Ma uscrip . he disser a io o compe i io scie ific degree of he ca dida e of medical scie ces i speciali y 14.01.03 – surgery. – a io al I s i u e of surgery a d ra spla a io amed af er A.A. Shalimov, Kyiv, 2008. he disser a io is devo ed o s udyi g of cha ges of a co di io lipid peroxida io , co di io s of sys em a ioxida pro ec io , he microcircula io a d fea ures repara ive processes a pa ie s wi h purule wou ds of sof issue a d o realiza io of heir correc io wi h he help of moder surgical rea me wi h he local pho ochemical ac iva io .
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