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Медико-биологические дисциплины
Наименование:

Mechanosensitivity in Cells and Tissues

Формат:      Страниц 464      Размер 24x16x3 см      Вес 0,97 кг
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Издательство:
Академия (Academia)    
Год:2006
Цена:
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International scientists have come together to create a book on mechanosensitivity in cells and tissues. Several stretch-induced signaling cascades have been described with multiple levels of crosstalk between the different pathways. The primary target for mechanical stimulation is the plasma membrane of the cell, which can respond to variable physical stress with changes of the open probability of mechanosensitive ion channels. A detailed study of the underlying mechanisms may therefore help to identify novel therapeutic targets fora future clinical use. Increased sensitivity of the cells to mechanical stress is found under various pathological conditions. This may ultimately influence the function of tissues and organs in health and disease. Thus, acting on ion channels in the plasma membrane, mechanical stress can elicit a multitude of biochemical processes inside a cell, both transient and long-lasting. Mechanosensitivity, i. e. the specific response to mechanical stimulation, is common to a wide variety of cells in many different organisms ranging from bacteria to mammals. Mechanical stress can modulate physiological processes at the molecular, cellular, and systemic level.
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